• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a device for packaging a sterile bulk, especially a dermo-cosmetic or galenic preparation, in a container (210), comprising: a. a sterile enclosure (101) and in this sterile enclosure, b. a hopper (200), containing the bulk, and comprising in axial direction a cylindrical reservoir portion (201) and a discharge portion (202); vs. a transfer device (115) capable of transporting the container (110) under the hopper (200) for filling in a so-called filling zone; d. a device (150) for ultra-filtered air blowing from the ceiling to the floor of the enclosure (101), able to produce an air flow, called a protective flow, around the filling zone; e. characterized in that the axis (205) of the discharge portion (202) of the hopper (200) is eccentric with respect to the axis (210) of the reservoir portion (201) so as to deport the orifice (206). ) discharge to the outer wall of the tank.
    公开号:FR3020800A1
    申请号:FR1454174
    申请日:2014-05-09
    公开日:2015-11-13
    发明作者:Bertrand Cormary；Laurent Serra
    申请人:Pierre Fabre Dermo Cosmetique SA；
    IPC主号:
    专利说明:

    [0001] The invention relates to an aseptic filling device and method. The invention is more particularly, but not exclusively, suitable for packaging dermo-cosmetic or galenic products, more particularly for packaging sterile cosmetic products.
    [0002] More specifically, the device and method that are the subject of the invention apply to the automated industrial packaging of a sterile product in bulk in a sterile individual container such as an ampoule, a bottle, a syringe or a tube, without this list is exhaustive. The packaged product is in the form of a liquid, a gel or a cream whose viscosity is generally between 600 Cps and 45,000 Cps (6 to 45 Pa. $). The term "sterile packaging" thus denotes the filling of a sterile container with a sterile product, the product thus conditioned having a defined degree of sterility without any post-conditioning sterilization being performed. According to an exemplary context of implementation of the invention, it is used for the packaging of a sterile dermo-cosmetic product produced in large quantities by a device and a method as described in document WO 2013 007755. According to the prior art, sterile dermo-cosmetic products without a biostatic formulation are packaged in containers of small capacity in order to limit the risks of retro-contamination of the product after the container has been opened, thus, once the open container, the product should be used very quickly. This packaging in small quantities, single dose, and the low shelf life after opening, limit the possibilities of commercial development of these products. These single-dose packages in a sterile medium are generally made according to a so-called "blow fill seal" process which does not make it possible to integrate a sophisticated occlusion device of the container and therefore remains limited to a single-dose packaging. These production methods of the prior art, have the disadvantage of coupling the production of containers and the production of sterile product. For example, product storage involves the same container storage and vice versa. The containers and the product must be produced at the same rate, which becomes complex to manage in terms of production flow when the product is presented for sale according to 3 02 0 80 0 2 several possible packaging. The use of a hermetic closure system of the container, as described in the document FR 2 873 358 makes it possible to eliminate the risks of retro-contamination of the product and opens the way to more usual packaging, for example in a tube of several hundred milliliters. However, if packaging facilities adapted to non-sterile preparations exist for this type of container, there is no sterile packaging line in the cosmetics or galenic field, able to absorb a production flow compatible with a sterilization process. as described in WO 2013 007755. According to alternative embodiments of the prior art, the product is sterilized after its packaging, in particular by subjecting said container comprising the product to ionizing radiation. This embodiment limits the choice of the type of container, in particular the material constituting it, its shape, which conditions the thickness of the product subjected to the ionizing action, inks used for decorating the container, without this list. is not exhaustive. According to the prior art, applied to non-sterile packaging, the bulk preparation is placed in a hopper and a transfer device brings the container under said hopper for filling. Throughout the text, the term "hopper" denotes a container including a spill-shaped portion, cone-shaped or reversed pyramid funneling and directing the container of the container to a discharge port, said container being cylindrical, section circular, rectangular or any other form According to the prior art applied to the packaging of sterilized food products, to protect from any contamination the bulk leaving the hopper and filling the container, a stream of ultra-filtered air is blown around the filling area. This airflow prevents particles from reaching the product spilled into the container. The document WO 2012 171958 describes a sterile packaging facility for foodstuffs, which installation is located in a sterile enclosure in which the filling zone is protected by a laminar airflow from the ceiling to the ground. These industrial installations of the prior art, adapted to the production of large volumes and designed essentially for foodstuffs, do not make it possible to obtain the performance required in terms of protection of the bulk during filling, when they are used for a period of time. application in the galenical or dermo-cosmetic field. Indeed, in the field of pharmaceutical or sterile cosmetics, sterility requirements are much higher than in the food industry.
    [0003] Thus, according to the EN 556 standard for medical devices and the European Pharmacopoeia, a product is said to be sterile, when its sterilization process makes it possible to reach a FO value of 15 minutes, that is to say the equivalent of exposure at a temperature of 121 ° C for 15 minutes. For sterile cosmetic preparations without preservatives, the sterilization reaches a FO of 22 minutes. By way of comparison, the ultra-high temperature sterilization of a food product, such as milk, corresponds to a FO of the order of 3 minutes. Thus, the turbulence generated in the protective air flow in the filling zone of the food product according to the prior art is sufficient to inadmissibly increase the probability of contamination of the bulk in the case of an application in the dermis range. -cosmetic. Indeed, although the environment is kept clean and sterile, given the volume of an industrial facility, there is always a risk that a particle can be introduced into the container or in the preparation at the time of filling. Paradoxically, the flow of protective air becomes, because of this turbulence, the main cause of contamination of the bulk.
    [0004] The invention aims to solve the disadvantages of the prior art and concerns for this purpose a device for packaging a sterile bulk, especially a dermo-cosmetic or galenic preparation, in a container, which device comprises: a. a sterile enclosure and in this sterile enclosure, b. a hopper, containing the bulk, and comprising in an axial direction, a cylindrical tank portion and a discharge portion; vs. a transfer device, able to transport under the hopper the container for filling in a so-called filling zone; d. an ultra-filtered air blowing device from the ceiling towards the floor of the enclosure, capable of producing an air flow, called a protective flow, around the filling zone; e. characterized in that the axis of the discharge portion of the hopper is eccentric with respect to the axis of the reservoir portion so as to deport the discharge port to the outer wall of the reservoir. Thus, the presence of the hopper does not disturb the laminar flow of the protective air flow in the filling zone, thus avoiding turbulence and eliminating the risk of contamination of the product when filling with particles brought by said flow of air. air. The invention is advantageously implemented according to the embodiments described below which are to be considered individually or in any technically operative combination. Advantageously, the device according to the invention comprises: f. suction means adapted to create a flow of air sweeping the transfer device. These means promote the production of a flow of laminar protective air around the filling zone, and direct any particle liable to contaminate the product to the suction means or it is discharged outside the filling zone.
    [0005] According to a particular embodiment, the device which is the subject of the invention is suitable for filling a flexible tube closed at one end, and comprises according to this embodiment: g. means for holding the flexible tube on the transfer device and having the open end of said tube under the discharge port; h. a sealing station of the open end of the tube, served by the transfer device after the filling zone, said sealing station being under the protective flow. Thus, the tubes are sealed under sterile conditions immediately after filling and the product discharged into the tube remains exposed only for a very short time in the air and always under an ultra-filtered air protection flow. Advantageously, the tube is made of a thermoplastic material and the crimping is performed by welding edge to edge of the open end of the tube. This embodiment is particularly economical and fast and ensures a perfectly tight closure of the open end of the tube. Advantageously, the initially closed end of the flexible tube is a stopper able to avoid retro-contamination of the product contained in said tube. Thus the product is advantageously packaged in containers adapted to regular use. Advantageously, the means for holding the flexible tube on the transfer device comprise a honeycomb container into which the flexible tubes are inserted. Thus, each batch of tube is supplied sterile mounted in its container, which is installed on the transfer device of the device object of the invention for packaging the product. The invention also relates to a process for the manufacture and packaging of a sterile bulk, in particular a dermo-cosmetic or galenical preparation, using a packaging device according to the invention, which process comprises the steps of: i. sterilizing the bulk in a device employing a steam infusion process; ii. transfer the bulk thus sterilized into the hopper of a packaging device according to the invention; Iii. supplying a sterile assembly comprising containers held in a honeycomb container; iv. packaging the bulk in the containers according to a filling process comprising the passage of said containers in their cellular container under the hopper of said conditioning device under an ultra-filtered laminar flow. This process makes it possible to produce sterile dermo-cosmetic or galenic preparations from unsterilized raw materials without post-packaging sterilization and thus offers great flexibility in terms of choice of raw materials, packaging, both in terms of volume and type of product. conditioning (tube, ampoule) than material constituting said conditioning. According to a variant of this method, step ii) is carried out by direct transfer of the infusion device to the hopper. This variant embodiment is suitable for just-in-time production on the same geographical site. The hopper serves as a buffer volume. According to another variant embodiment, the method which is the subject of the invention comprises, between step i) and step ii), a step consisting of: y. storing the sterilized bulk in a closed sterile tank, step ii) being performed by transferring the bulk of said tank into the hopper. This embodiment variant allows the sterilization of the bulk on one geographical site and its packaging on another. More generally, it offers more flexibility in the management of production.
    [0006] According to a particularly advantageous embodiment, the method which is the subject of the invention before step i) a step consisting in: vi sterilizing the entire installation by the circulation in said installation of high temperature steam produced by the means sterilization by infusion.
    [0007] Thus, the steam produced by the device used for the production makes it possible to sterilize the entire installation without the addition of a particular device. The installation is thus adapted to a quick change of series. The invention is explained below according to its preferred embodiment, in no way limiting, and with reference to FIGS. 1 to 5 in which: FIG. 1, relating to the prior art, schematically represents an exemplary embodiment of a sterile packaging device adapted, for example to the packaging of a foodstuff; FIG. 2 shows in a diagrammatic representation an exemplary embodiment of a device for packaging a sterile bulk according to the invention; - Figure 3 schematically illustrates an embodiment of a plant for the production and packaging of a sterile dermo-cometic product; FIG. 4 shows an exemplary embodiment of a container of a sterile dermo-cosmetic preparation according to the invention, FIG. 4A, according to a front view in section, before the filling of said container, held in a cellular container and Figure 4B according to a front view after filling and crimping; and FIG. 5 is a logic diagram of the process for packaging a sterile bulk according to the invention. Figure 1, according to an exemplary embodiment of the prior art applied in particular to the case of filling a container (110) with a foodstuff, the bulk is contained in a hopper (100). The product is discharged from the hopper (100) into the container (110) through a filling spout connected to the discharge port (106) of the hopper (100). The containers (110) are carried by a transfer device (115) which brings them from a loading station (120) to an unloading station (130). The entire machine is included in an enclosure (101) whose access is achieved by an airlock. After filling, the container (110) is closed and sealed by a closure device (140) before being directed to the unloading station (130).
    [0008] To ensure the absence of contamination by particles during filling, a blower device (150) generates an ultra-filtered airflow from the ceiling to the floor of the device. This air flow (151) is predominantly laminar in the volume of the enclosure, however, the presence of the hopper (100) creates turbulence (152) in this air flow, more particularly at the level of the filling. This turbulence is likely to lead to contamination of the containers by particles. In the case where the bulk is a food product, the risk of contamination generated by these turbulences is acceptable the enclosure of the machine itself being clean and sterilized. In the case of a cosmetic product without preservatives, the sterility rate required does not allow to tolerate such a risk of contamination.
    [0009] FIG. 2, in order to overcome these drawbacks of the prior art, the device that is the subject of the invention uses a specific hopper (200), comprising a cylindrical portion (201), followed axially by a portion (202), said spill, connected to the portion (201) cylindrical asymmetrical conical shape. The axis (205) on which is located the apex of the cone defining the shape of the discharge portion (202) is eccentric with respect to the axis (210) of the cylindrical portion (201). Thus, the orifice (206) of discharge of the hopper, orifice substantially centered on the axis (205) bearing the top of the cone in the shape of the part (202) of discharge, is eccentric to the outer wall of the part (201) reservoir of said hopper (200). This arrangement makes it possible to maintain a laminar flow in the filling zone of the container and thus considerably limit the risk of contamination of the product by particles during filling. Indeed, according to this arrangement, the portion (201) cylindrical, said tank, does not hide the filling area vis-à-vis the flow (150) of air from the ceiling. The device according to the invention comprises, according to this embodiment, a device (250) suction is placed under the device (115) of transfer. This suction device creates a sweeping of said transfer device by a flow of air and also promotes, in the configuration of the device object of the invention, the creation of a laminar flow around the filling zone. According to this exemplary embodiment, the container (110) is a tube whose one end is open for filling and the other end is closed by a specific plug (211), able to prevent any retro-contamination of the product contained in the tube. during the use of said tube by the consumer. The envelope of the tube (110) is made of a thermoplastic material and the closure of the container is made by welding the edges of the open end. According to this embodiment, said tubes have a capacity of 50 ml and 450 ml without these values being limiting. According to this example, the bulk is a dermo-cosmetic product in the form of an emulsion whose viscosity is between 600 Cps and 45,000 Cps.
    [0010] 3, according to an exemplary embodiment of the method which is the subject of the invention, the dermo-cosmetic or galenic preparation (300) is sterilized by heat according to a so-called UHT method for "ultra-high temperature". For this purpose, and according to this embodiment, during a preheating step (310), said preparation is brought to a suitable temperature, in particular to give it a viscosity adapted to the targeted sterilization treatment. According to this exemplary embodiment, the sterilization step (320) is carried out by infusion. According to this method, the preheated preparation is introduced as a shower into an enclosure (321) comprising clean water vapor at a defined temperature. The heating of the preparation is instantaneous because of the large exchange surface between the nets of the preparation and the steam, and the condensation of the steam on said nets. The preparation is maintained (322) at this temperature for a very short time, depending on the targeted sterilization level, before being injected into a chamber (323) under vacuum where said preparation undergoes a very rapid cooling, due to the vaporization , under the effect of vacuum, condensed water during the heating phase (321). The preparation is then cooled (330) gradually with stirring to a favorable temperature for its conditioning, for example a temperature between 30 ° C and 40 ° C. The preparation is, according to this embodiment, stored in a closed buffer tank (340). Said tank (340) buffer is, according to an embodiment of the method of the invention, connected by a pipe (345) to the hopper (200) of the packaging device object of the invention. The sterilization conditions, namely the temperature and the preheating rate, the temperature and the duration of the infusion sterilization as well as the cooling rate after the sterilization are selected so that the emulsion constituting the preparation is not broken at during this process, that is to say that said preparation does not lose its emulsifying character and retains its organoleptic characteristics. Thus, the sterilized preparation by the infusion process is transferred as a sterile bulk into the conditioning device without further processing. The transfer of the bulk into the hopper (200) is accomplished by sterile lines (345) so that the bulk is not in contact with the air, eliminating any risk of contamination prior to filling. Advantageously, according to this configuration of implementation of the method which is the subject of the invention, the steam generator of the infusion sterilization device (320) is used to sterilize the entire installation, by the circulation of steam in the plant. assembly of the production-conditioning circuit, that is to say in particular the pipes, the heating-cooling devices, the buffer tank (340) and the hopper (200), when the said circuit is emptied of the presence of any product . Alternatively, the sterile preparation is stored in the tank (340) sealed buffer, and transported to a place of packaging remote from the sterilization site. 4A, prior to the conditioning operation, the empty sterile tubes (110) are installed in a honeycombed container (415), for example consisting of cellular polypropylene plates. Specific plugs (211), preventing back-contamination, are installed at the end of said tubes (110). The whole is sterilized and bagged. By way of non-limiting example, the envelope (410) of the tube (110) consists of monolayer polyethylene. According to an alternative embodiment, the jacket of the tube is multilayer and comprises a layer of an oxygen impermeable polymer. According to alternative embodiments, the envelope (410) of the tube (110) is made of a metallic material. In practice, the method and the object of the invention do not involve post-conditioning sterilization, the choice of material constituting the tube is very wide. Figure 4B, the filled tubes not undergoing other sterilization operation, the empty tubes are installed printed in the honeycomb containers. Advantageously, the tube (110) and said container (415) comprise markers (not shown) capable of cooperating to correctly orient the printed portion (420) of the tube opposite the weld line (440) closing the tube once. this one filled. FIG. 5, the method which is the subject of the invention makes it possible to obtain, according to an industrial production method, with production flows of the order of 2000 Kg per hour, a sterile dermo-cosmetic or galenic product, without preservative, in a containing directly available for retail sale and including all the required particulars and the appropriate distinguishing marks. Said method comprises a step (510) for producing a sterile bulk, in particular by means of an infusion sterilization method, and, in parallel, a step (520) for supplying sterile container containers, said sterile assembly, particularly in a bagged cellular container. Thus, unlike methods of the prior art of the "blow fill seal" type for single-dose packages, or sterilization of the product in the container, the method that is the subject of the invention makes it possible to decouple the two production streams and thus to offer increased production flexibility while retaining the benefits of tense flow. According to a step (525) for preparing the containers, the container is extracted from its bagging and installed on the table of the packaging device according to the invention, all in clean environment. In parallel, according to a step (515) of bulk supply, the sterile bulk produced in the preceding step (510) is introduced into the hopper of the filling device object of the invention. According to variants of the method that is the subject of the invention, the bulk thus introduced into the hopper comes directly from the sterilization device or the hopper is fed from a sterile tank. The containers and the bulk being transferred into the packaging device, the containers are filled and sealed during a step (530) of filling. The above description and the exemplary embodiments show that the invention achieves the desired objectives, in particular, it allows, according to a flexible and just-in-time industrial production process, to produce a sterile dermo-cosmetic or galenic preparation, according to flow rates. high production, ensuring high sterility, ie with a FO greater than 15 minutes, all along the production line.
    权利要求:
    Claims (10)
    [0001]
    REVENDICATIONS1. Device for packaging a sterile bulk, especially a dermo-cosmetic or galenic preparation, in a container (110), comprising: a. a sterile enclosure (101) and in this sterile enclosure, b. a hopper (200), containing the bulk, and comprising in axial direction a cylindrical reservoir portion (201) and a discharge portion (202); vs. a transfer device (115) capable of transporting the container (110) under the hopper (200) for filling in a so-called filling zone; d. a device (150) for ultra-filtered air blowing from the ceiling to the floor of the enclosure (101), able to produce an air flow, called a protective flow, around the filling zone; e. characterized in that the axis (205) of the discharge portion (202) of the hopper (200) is eccentric with respect to the axis (210) of the reservoir portion (201) so as to deport the orifice (206). ) discharge to the outer wall of the tank.
    [0002]
    2. Device according to claim 1, comprising: f. suction means (250) capable of creating a flow of air sweeping the transfer device (115).
    [0003]
    3. Device according to claim 1, wherein the container (110) is a flexible tube, closed at one end, which device comprises: g. means (415) for holding the flexible tube on the transfer device and having the open end of said tube (110) under the discharge port; h. a sealing station (140) of the open end of the tube, served by the transfer device after the filling zone, said sealing station being under the protective flow.
    [0004]
    4. Device according to claim 3, wherein the tube (110) is made of a thermoplastic material and wherein the sealing is performed by a weld (440) edge to edge of the open end of said tube.
    [0005]
    5. Device according to claim 3, wherein the initially closed end of the flexible tube is a plug (211) adapted to avoid the retro-contamination of the product contained in said tube.
    [0006]
    6. Device according to claim 3, wherein the means for holding the flexible tube on the transfer device comprises a container (415) cellular in which are inserted the tubes (110) flexible.
    [0007]
    7. Process for the manufacture and packaging of a sterile bulk, especially a dermo-cosmetic or galenic preparation, using a packaging device according to claim 1, characterized in that it comprises the steps of: i. sterilizing (510) the bulk in a device employing a steam infusion process; ii. transferring (515) the thus sterilized bulk into the hopper of a packaging device according to claim 1; iii. supplying (520) a sterile assembly comprising containers mounted in a honeycomb container; iv. packaging (530) the bulk in the containers according to a filling process comprising the passage of said cotenants in their cellular container under the hopper of said conditioning device in an ultra-filtered laminar flow.
    [0008]
    The method of claim 7, wherein step ii) is performed by direct transfer from the steam infusion device to the hopper.
    [0009]
    The method of claim 7, comprising between step i) and step ii) a step of: y. storing the sterilized bulk in a closed sterile vat (340), step ii) being performed by transferring the bulk of said vat to the latrine.
    [0010]
    The method of claim 7, comprising before step i) a step of: sterilizing the entire plant by circulating in said high temperature steam plant produced by the infusion sterilizing device.
    类似技术:
    公开号 | 公开日 | 专利标题
    EP3074313B1|2017-04-26|Device and method for aseptic filling
    EP1896329B2|2017-11-22|Installation for producing sterile bottles by blow molding sterilized preforms
    CA2147414C|2007-06-26|Process for filling a sealed recipient in aseptic conditions
    EP3157821B1|2021-04-14|Method of manufacturing spouted pouch aseptically filled with contents
    FR2910329A1|2008-06-27|METHOD AND DEVICE FOR STERILIZING PREFORMS
    WO2006136499A1|2006-12-28|Method for sterilizing preforms and installation for producing sterile bodies from these preforms
    FR2963328A1|2012-02-03|DISPOSABLE PACKAGING ARTICLE
    EP3189737B1|2019-05-15|Continuous method and system of devices for pasteurising or sterilising foodstuffs in a rigid container followed by deep-vacuum sealing of same by rotary steam injection and uniform rapid cooling
    EP3250241B1|2021-06-30|Device and method for sterilizing thermoplastic containers using a pulsed electron beam and a mobile reflector
    FR2695108A1|1994-03-04|Sealed foodstuff container envelope with pressure release device - has small hole formed in edge portion of flexible film envelope, surrounded by internal adhesive area allowing pressure release and resealing
    EP2226252B1|2012-09-05|Method and installation for continuous vacuum packing of food products
    EP1799174B1|2009-08-12|Storage assembly for contrast media
    FR2491032A1|1982-04-02|METHOD OF STERILIZING PACKAGING MATERIAL
    FR2818615A1|2002-06-28|Bottle filling installation, for products which may be degraded by oxygen, comprises cleaning-filling-sealing units contained inside compartment partially filled with inert gas
    CA2936135A1|2015-07-30|Device and method for transferring a sterile product between two containers
    FR2799730A1|2001-04-20|MACHINE FOR FILLING AND SEALING CONTAINERS
    FR2768594A1|1999-03-26|Sterilization of food products before packaging
    JP2013086848A|2013-05-13|Sterile filling method of container with tap
    JP2002347716A|2002-12-04|Method for gas exchange in packing viscous substance in container
    WO2018091809A1|2018-05-24|Medical bag with two compartments and including a tab
    FR2915736A1|2008-11-07|Liquid or gas sucking and injecting device for hermetic package, has sealed chamber with gas or liquid introducing and evacuating unit, and movable transfer needle perforated to package and communicated with sealed chamber
    同族专利:
    公开号 | 公开日
    JP2017520481A|2017-07-27|
    CN107074378B|2019-11-05|
    EP3074313B1|2017-04-26|
    WO2015169972A1|2015-11-12|
    JP6665114B2|2020-03-13|
    CA2948427A1|2015-11-12|
    FR3020800B1|2017-08-25|
    EP3074313A1|2016-10-05|
    CN107074378A|2017-08-18|
    US20170240310A1|2017-08-24|
    ES2633498T3|2017-09-21|
    BR112016026149B1|2021-05-04|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    EP0096336A2|1982-06-09|1983-12-21|NUOVA ZANASI S.p.A.|Apparatus for filling containers in a sterile environment|
    WO1996029556A1|1995-03-18|1996-09-26|The Wellcome Foundation Limited|Freeze-drying process and apparatus|
    WO2004026735A2|2002-09-17|2004-04-01|Glaxosmithkline Biologicals S.A.|Article holding means and conveyor system|
    EP1561686A1|2004-02-03|2005-08-10|Tonazzi S.r.l.|Machine for filling and closing tubes|
    US20080184671A1|2005-06-10|2008-08-07|Tim Fleckenstein|Container Filling and Locking Device|
    EP2179925A1|2008-10-17|2010-04-28|CO.RI.M.A. S.r.l.|A machine for filling vials|
    WO2012171958A1|2011-06-15|2012-12-20|Serac Group|Aseptic packaging plant with aseptic buffer regions|
    WO2013007755A1|2011-07-11|2013-01-17|Pierre Fabre Dermo-Cosmetique|Device and method for sterilizing an emulsion at an ultrahigh temperature, particularly a cosmetic emulsion for the skin, which is unstable at the sterilization temperature|
    US2943752A|1959-06-30|1960-07-05|Farmers Cooperative Exchange|Bulk feed bin|
    IT1179332B|1984-05-09|1987-09-16|I M A Indu Macchine Automatich|"METHOD FOR THE PREPARATION AND PACKAGING OF PREFORMED TUBULAR TUBULAR CONTAINERS IN CARTONS INTUBETTING MACHINE|
    US4590734A|1984-06-04|1986-05-27|Shikoku Kakooki Co., Ltd.|Packaging machine|
    US4702364A|1986-05-09|1987-10-27|Johanneck Richard G|Silo chute hopper attachment|
    US4989649A|1989-09-14|1991-02-05|Automatic Liquid Packaging, Inc.|Fill machine sterilization process|
    DE4226566C2|1992-08-12|1996-04-18|Jagenberg Ag|Device for dosing and filling liquid or pasty products|
    WO1996006009A1|1994-08-23|1996-02-29|Pharma-Tech Co., Ltd.|Powder filling apparatus|
    IES940660A2|1994-08-23|1996-01-24|Faircove Systems|Improvements in and relating to dispensing apparatus|
    AU727887C|1996-11-04|2001-08-23|Jerry R. Johanson|Archbreaking hopper for bulk solids|
    US6134866A|1998-12-29|2000-10-24|Vital Signs, Inc.|Apparatus for manufacturing articles|
    US6209591B1|1999-02-02|2001-04-03|Steuben Foods, Inc.|Apparatus and method for providing container filling in an aseptic processing apparatus|
    JP2002046704A|2000-08-03|2002-02-12|Seiko Engineering Kk|Subdivision pack apparatus for powdered material|
    DE10357004A1|2003-12-05|2005-06-30|Merck Patent Gmbh|Flavonoid derivative|
    FR2873358B1|2004-07-20|2006-11-10|Sivel Soc Civ Ile|DEVICE FOR PACKAGING AND DISPENSING A PRODUCT WITH A STERILE FILTER BOTTLE WITH A TIP|
    US9004317B2|2004-07-20|2015-04-14|Sivel|Product packaging and dispensing device comprising a sterile filter bottle which is equipped with a nozzle|
    ITBO20040626A1|2004-10-13|2005-01-13|Marchesini Group Spa|MACHINE FOR PACKAGING PRODUCTS IN A PROTECTED ENVIRONMENT|
    ITPI20040091A1|2004-12-07|2005-03-07|Marco Bianchi|DISTRIBUTOR FOR HOT FOOD PRODUCT|
    ITBO20050010A1|2005-01-12|2006-07-13|Ima Spa|COMPACT SYSTEM FOR PACKAGING IN STERILE ENVIRONMENT OF LIQUID PRODUCTS INJECTED IN CONTAINERS|
    JP4875870B2|2005-09-05|2012-02-15|塩野義製薬株式会社|Powder supply apparatus, powder supply method, powder supply and filling apparatus, and powder supply and filling method|
    ITBO20070071A1|2007-02-07|2008-08-08|Marchesini Group Spa|MACHINE FOR FILLING AND CLOSING OF CONTAINERS|
    DE102007042433A1|2007-09-06|2009-03-12|Iwk Verpackungstechnik Gmbh|Method and device for filling tubes in a tube filling machine|
    EP2303222B1|2008-06-27|2013-04-24|Basf Se|Stabilization of body-care and household products|
    DE102009027452A1|2009-07-03|2011-01-05|Robert Bosch Gmbh|Device for filling and closing pharmaceutical containers|
    US8621824B2|2009-09-29|2014-01-07|American Sterilizer Company|Bottle decontamination system|
    US9623988B2|2010-03-26|2017-04-18|Philip Morris Usa Inc.|High speed poucher|
    JP5803075B2|2010-09-03|2015-11-04|株式会社タカゾノテクノロジー|Drug supply device|
    CN107207103B|2015-02-11|2020-03-03|高露洁-棕榄公司|Tube holder for filling machine|IT201600082954A1|2016-08-05|2018-02-05|Fater Spa|PLANT FOR THE PRODUCTION OF COSMETIC PRODUCTS, IN PARTICULAR FOR THE PRODUCTION OF HUMIDIFIED WIPES|
    FR3055409B1|2016-08-26|2020-06-12|Pierre Fabre Dermo-Cosmetique|METHOD AND DEVICE FOR THE CONTINUOUS TESTING OF THE SEALING OF A WELD AT THE END OF A TUBE CONTAINING A PRODUCT|
    CN108238291B|2018-04-24|2018-11-27|嵊州市诺米克进出口有限公司|A kind of adjuvant therapy medicaments of tumor bottle filling device|
    WO2021154894A1|2020-01-27|2021-08-05|Sanfilippo Tech, Llc.|System for aseptic packaging and method of using the same|
    法律状态:
    2015-05-29| PLFP| Fee payment|Year of fee payment: 2 |
    2015-11-13| PLSC| Search report ready|Effective date: 20151113 |
    2016-05-31| PLFP| Fee payment|Year of fee payment: 3 |
    2017-05-30| PLFP| Fee payment|Year of fee payment: 4 |
    2018-05-31| PLFP| Fee payment|Year of fee payment: 5 |
    2019-05-31| PLFP| Fee payment|Year of fee payment: 6 |
    2020-05-30| PLFP| Fee payment|Year of fee payment: 7 |
    2021-05-31| PLFP| Fee payment|Year of fee payment: 8 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1454174A|FR3020800B1|2014-05-09|2014-05-09|DEVICE AND METHOD FOR ASEPTIC FILLING|FR1454174A| FR3020800B1|2014-05-09|2014-05-09|DEVICE AND METHOD FOR ASEPTIC FILLING|
    CN201580036797.3A| CN107074378B|2014-05-09|2015-05-11|Aseptic filling device and method|
    PCT/EP2015/060394| WO2015169972A1|2014-05-09|2015-05-11|Aseptic filling device and method|
    JP2016567371A| JP6665114B2|2014-05-09|2015-05-11|Aseptic filling device and method|
    BR112016026149-6A| BR112016026149B1|2014-05-09|2015-05-11|sterile bulk packaging device and sterile bulk manufacturing and packaging process|
    CA2948427A| CA2948427A1|2014-05-09|2015-05-11|Aseptic filling device and method|
    US15/310,093| US20170240310A1|2014-05-09|2015-05-11|Aseptic filling device and method|
    EP15720105.4A| EP3074313B1|2014-05-09|2015-05-11|Device and method for aseptic filling|
    ES15720105.4T| ES2633498T3|2014-05-09|2015-05-11|Aseptic filling method and device|
    [返回顶部]